top of page

Our Laboratory's Research

Lab Reasearch

Functional genomics of organelles 
One of the hallmarks of eukaryotic cells is the presence of membrane-enclosed organelles that create optimized environments best suited for promoting the various chemical reactions required to sustain life. Although more than 15 years have passed since the publication of the Saccharomyces cerevisiae genome sequence, over 30% of the proteins that reside in its organelles have never been studied and more than half of them do not have a known biochemical function. Most of these proteins are conserved all the way to humans and some have been implicated in diseases. One of the great challenges of the post-genomic era is, therefore, to use novel methodologies to fill in these gaps in our knowledge, to uncover the functions of these unstudied proteins, and to delineate pathways and networks that enable the function and communication of these organelles. Our lab is dedicated to uncovering novel functions for yeast organellar proteins. We do this by employing a wide variety of high throughput screening techniques complemented by dedicated cell biological, genetic and biochemical follow ups.


Individual research

Will robots take over the world?

Individual Research


Emma's Research

Understanding how the ER is organized into subdomains

Emma is interested in the endoplasmic reticulum (ER) and how this extensive organelle, built from one continuous membrane, is compartmentalized into specialized regions required for its diverse functions. To do this, she is using different technologies to map distinct regions and the proteins that reside in them.


Ofir's Research

Development of a fast diagnostic test for peroxisomal diseases

Ofir is screening a library of fluorescent compounds to identify a synthetic dye which specifically labels peroxisomes. The dye will be tested for its universality and ease of use. Identifying a peroxisomal dye will simplify staining and imaging procedures of peroxisomes for research and significantly expand the diagnostic toolkit for peroxisomal diseases.

Comic research for webpage Sarah TIFF-1.tif

Sarah's Research

Development of Multi-CLEM in mammalian


Sarah is developing a high-throughput screening approach (multi-CLEM) for electron microscopy in mammalian cells. The combination of fluorescence microscopy for barcoding of tens or hundreds of differently manipulated cells and electron microscopy will allow quantitative imaging at the ultrastructure level.


Naama's Research

Characterizing new mitochondrial contact sites

Naama is interested in finding and characterising new contact sites for mitochondria. Using high throughput screens and microscopy Naama aims to discover new tethering molecules, regulators and functions for such contacts. 

Image (330).jpg

Sivan's Research

Uncovering new targeting factors of proteins to the ER

Sivan is interested in how proteins with unique targeting signals are targeted to the Endoplasmic Reticulum (ER) in yeast. Sivan hopes to discover new factors involved in the process. To do this, she uses high throughput screens of mutant libraries combined with image analysis.

Image (333).jpg

Lior's Research

Discovering New Peroxisomal Proteins Via a Novel Fluorescent Genomic Library

Lior is interested in using new fluorescently tagged genomic libraries for the identification of new peroxisomal proteins. Lior wishes to uncover the targeting pathways that they take to reach peroxisomes and elucidate their biological features and function.


Rosario's Research

Identifying new enzymes in yeast

Rosario is interested in uncovering enzymes previously unidentified. By transiently depleting the proteins on demand, Rosario aims to use the metabolic changes that follow to trace back the function of new enzymes.

Noga reasurch image.png

Noga's Research

Uncovering new membrane shaping proteins in mitochondria

Noga is interested in the unique structure of mitochondria, forming a continuous branched network in the cell. Using high throughput screens and microscopy, Noga aims to discover new membrane shaping proteins that enable the formation of this intricate structure.


Israel Science Foundation.jpg

ERC CoG 646604

bottom of page