Functional genomics of organelles
Maya Schuldiner Lab
If you want to see all publications that our lab has contributed to including collaborative projects please see PubMed:
Here are the central manuscripts that we led:
2022 Publications
Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution
eLife 2022 November
Inês Gomes Castro, Shawn P Shortill, Samantha Katarzyna Dziurdzik, Angela Cadou, Suriakarthiga Ganesan, Rosario Valenti, Yotam David, Michael Davey, Carsten Mattes, Ffion B Thomas, Reut Ester Avraham, Hadar Meyer, Amir Fadel, Emma J Fenech, Robert Ernst, Vanina Zaremberg, Tim P Levine, Christopher Stefan, Elizabeth Conibear, Maya Schuldiner
Determining the targeting specificity of the selective peroxisomal targeting factor Pex9
Biological Chemistry 2022 October
Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions
Molecular Systems Biology 2022 September
Eden Yifrach, Duncan Holbrook-Smith, Jérôme Bürgi, Alaa Othman, Miriam Eisenstein, Carlo WT van Roermund, Wouter Visser, Asa Tirosh, Markus Rudowitz, Chen Bibi, Shahar Galor, Uri Weill, Amir Fadel, Yoav Peleg, Ralf Erdmann, Hans R Waterham, Ronald J A Wanders, Matthias Wilmanns, Nicola Zamboni, Maya Schuldiner, Einat Zalckvar
Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis
Cells 2022 April
Yotam David, Inês Gomes Castro, Eden Yifrach, Chen Bibi, Enas Katawi, Dekel Yahav Har-Shai, Sagie Brodsky, Naama Barkai, Tommer Ravid, Miriam Eisenstein, Shmuel Pietrokovski, Maya Schuldiner, Einat Zalckvar
A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase
Journal of Molecular Biology 2022 April
Nir Cohen, Amit Kahana, Maya Schuldiner
Peroxisome function relies on organelle-associated mRNA translation
Science Advances 2022 January
Noa Dahan, Yury S Bykov, Elizabeth A Boydston, Amir Fadel, Zohar Gazi, Hodaya Hochberg-Laufer, James Martenson, Vlad Denic, Yaron Shav-Tal, Jonathan S Weissman, Naama Aviram, Einat Zalckvar, Maya Schuldiner
Beyond rare disorders: A new era for peroxisomal pathophysiology
Molecular Cell 2022 June
Show your true color: Mammalian cell surface staining for tracking cellular identity in multiplexing and beyond
Current Opinion in Chemical Biology November 2022 February
Sarah Hassdenteufel, Maya Schuldiner
2021 Publications
The Fast and the Furious: Golgi Contact Sites
SAGE journals 2021 August
Yotam David , Inês G. Castro, and Maya Schuldiner
Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels
JCB journal of cell biology 2021 November
Michal Eisenberg-Bord, Naama Zung, Javier Collado, Layla Drwesh, Emma J. Fenech, Amir Fadel, Nili Dezorella, Yury S. Bykov, Doron Rapaport, Ruben Fernandez-Busnadiego, and Maya Schuldiner
Widespread use of unconventional targeting signals in mitochondrial ribosome proteins
The EMBO journal 2021 November
Yury S. Bykov, Tamara Flohr, Felix Boos, Naama Zung, Johannes M. Herrmann, Maya Schuldiner
2020 Publications
New horizons in mitochondrial contact site research
Biological Chemistry 2020 May
Naama Zung, Maya Schuldiner
A piggybacking mechanism enables peroxisomal localization
of the glyoxylate cycle enzyme Mdh2 in yeast
Journal of Cell Science 2020
Shiran Gabay-Maskit, Luis Daniel Cruz-Zaragoza, Nadav Shai, Miriam Eisenstein, Chen Bibi,
Nir Cohen, Tobias Hansen, Eden Yifrach, Nofar Harpaz, Ruth Belostotsky, Wolfgang Schliebs,
Maya Schuldiner, Ralf Erdmann and Einat Zalckvar
Uncovering targeting priority to yeast peroxisomes using an in-cell competition assay.
PNAS, 2020 Aug
Rosenthal M, Metzl-Raz E, Bürgi J, Yifrach E, Drwesh L, Fadel A, Peleg Y, Rapaport D, Wilmanns M, Barkai N, Schuldiner M, Zalckvar E.
Double the Fun, Double the Trouble: Paralogs and Homologs Functioning in the Endoplasmic Reticulum
Annual Review of Biochemistry 2020 Jun
Cytosolic Events in the Biogenesis of Mitochondrial Proteins.
Cell Press, 2020 May
Yury S. Bykov, Doron Rapaport, Johannes M. Herrmann and Maya Schuldiner
2019 Publications
The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis.
Contact 2019 Feb
Michal Eisenberg-Bord, Hui S. Tsui, Diana Antunes, Lucía Fernández-del-Río, Michelle C. Bradley, Cory D. Dunn Theresa P. T. Nguyen, Doron Rapaport, Catherine F. Clarke, and Maya Schuldiner
Promethin Is a Conserved Seipin Partner Protein
Cells 2019 Mar
Coming together to define membrane contact sites.
Nature communications 2019 Mar.
2018 Publications
Assessment of GFP tag position on protein localization and growth fitness in yeast
J Mol Biol. 2018 Dec
Genome-wide SWAp-Tag yeast libraries for proteome exploration
Nat Methods. 2018 Jul
Weill U, Yofe I, Sass E, Stynen B, Davidi D, Natarajan J, Ben-Menachem R, Avihou Z, Goldman O, Harpaz N, Chuartzman S, Kniazev K, Knoblach B, Laborenz J, Boos F, Kowarzyk J, Ben-Dor S, Zalckvar E, Herrmann JM, Rachubinski RA, Pines O, Rapaport D, Michnick SW, Levy ED, Schuldiner M.
Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
Nat Commun. 2018 May
Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M and Zalckvar E.
2017 Publications
Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis
J Proteome Res. 2017 Feb
Lebesgue N, Megyeri M, Cristobal A, Scholten A, Chuartzman SG, Voichek Y, Scheltema RA, Mohammed S, Futerman AH, Schuldiner M, Heck AJ, Lemeer S.
2016 Publications
A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites
Dev Cell. 2016 Nov
Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor
J Cell Sci. 2016 Sep
Making sense of the yeast sphingolipid pathway
J Mol Biol. 2016 Sep
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy
Nat Methods. 2016 Feb
Water-Transfer Slows Aging in Saccharomyces cerevisiae
PLoS One. 2016 Feb
Copy Of -Water-Transfer Slows Aging in Saccharomyces cerevisiae
PLoS One. 2016 Feb
2015 Publications
2014 Publications
2013 Publications
2012 Publications
Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis.
Proc Natl Acad Sci U S A. 2012 Nov
Nadler-Holly M, Breker M, Gruber R, Azia A, Gymrek M, Eisenstein M, Willison KR, Schuldiner M, Horovitz A.
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes.
Mol Biol Cell. 2012 Oct
Krumpe K, Frumkin I, Herzig Y, Rimon N, Özbalci C, Brügger B, Rapaport D, Schuldiner M.
A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14.
PLoS Biol. 2012 May
Herzig Y, Sharpe HJ, Elbaz Y, Munro S, Schuldiner M.
2011 Publications
Getting the whole picture: combining throughput with content in microscopy
J Cell Sci. 2011 Nov
Rimon N, Schuldiner M.
Staying in touch: the molecular era of organelle contact sites.
Trends Biochem Sci. 2011 Nov
Elbaz Y, Schuldiner M.
Advanced methods for high-throughput microscopy screening of genetically modified yeast libraries
Methods Mol Biol. 2011
Cohen Y, Schuldiner M.
2005-2010 Publications
Explorations in topology-delving underneath the surface of genetic interaction maps.
Mol Biosyst. 2009 Dec
Breker M, Schuldiner M.
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
Science. 2009 Mar
Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M.
The GET complex mediates insertion of tail-anchored proteins into the ER membrane.
Cell. 2008 Aug
Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS.
Identification of yeast proteins necessary for cell-surface function of a potassium channel.
Proc Natl Acad Sci U S A. 2007 Nov
Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M.
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.
Cell. 2005 Nov
Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ.