2025 Publications
Profiling the LAM Family of Contact Site Tethers Provides Insights into Their Regulation and Function
Contact
Emma J. Fenech, Meital Kupervaser, Angela Boshnakovska,
Shani Ravid, Inês Gomes Castro, Yeynit Asraf, Sylvie Callegari, Christof Lenz, Henning Urlaub, Peter Rehling, Maya Schuldiner
2024 Publications
A proteome-wide yeast degron collection for the dynamic study of protein function
JCB
Rosario Valenti , Yotam David , Dunya Edilbi, Benjamin Dubreuil, Angela Boshnakovska, Yeynit Asraf , Tomer-Meir Salame , Ehud Sass, Peter Rehling, Maya Schuldiner
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A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes
eLife
2023 Publications
2022 Publications
Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution
eLife
Inês Gomes Castro, Shawn P Shortill, Samantha Katarzyna Dziurdzik, Angela Cadou, Suriakarthiga Ganesan, Rosario Valenti, Yotam David, Michael Davey, Carsten Mattes, Ffion B Thomas, Reut Ester Avraham, Hadar Meyer, Amir Fadel, Emma J Fenech, Robert Ernst, Vanina Zaremberg, Tim P Levine, Christopher Stefan, Elizabeth Conibear, Maya Schuldiner
Determining the targeting specificity of the selective peroxisomal targeting factor Pex9
Biological Chemistry
Eden Yifrach, Markus Rudowitz, Luis Daniel, Cruz-Zaragoza, Asa Tirosh, Zohar Gazi, Yoav Peleg, Markus Kunze, Miriam Eisenstein, Wolfgang Schliebs, Maya Schuldiner, Ralf Erdmann, Einat Zalckvar
Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions
Molecular Systems Biology
Eden Yifrach, Duncan Holbrook-Smith, Jérôme Bürgi, Alaa Othman, Miriam Eisenstein, Carlo WT van Roermund, Wouter Visser, Asa Tirosh, Markus Rudowitz, Chen Bibi, Shahar Galor, Uri Weill, Amir Fadel, Yoav Peleg, Ralf Erdmann, Hans R Waterham, Ronald J A Wanders, Matthias Wilmanns, Nicola Zamboni, Maya Schuldiner, Einat Zalckvar
Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis
Cells
Peroxisome function relies on organelle-associated mRNA translation
Science Advances
Beyond rare disorders: A new era for peroxisomal pathophysiology
Molecular Cell
Show your true color: Mammalian cell surface staining for tracking cellular identity in multiplexing and beyond
Current Opinion in Chemical Biology
Sarah Hassdenteufel, Maya Schuldiner
2021 Publications
The Fast and the Furious: Golgi Contact Sites
SAGE journals
Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels
JCB journal of cell biology
Michal Eisenberg-Bord, Naama Zung, Javier Collado, Layla Drwesh, Emma J. Fenech, Amir Fadel, Nili Dezorella, Yury S. Bykov, Doron Rapaport, Ruben Fernandez-Busnadiego, and Maya Schuldiner
2020 Publications
New horizons in mitochondrial contact site research
Biological Chemistry
A piggybacking mechanism enables peroxisomal localization of the glyoxylate cycle enzyme Mdh2 in yeast
Journal of Cell Science
Shiran Gabay-Maskit, Luis Daniel Cruz-Zaragoza, Nadav Shai, Miriam Eisenstein, Chen Bibi, Nir Cohen, Tobias Hansen, Eden Yifrach, Nofar Harpaz, Ruth Belostotsky, Wolfgang Schliebs,
Maya Schuldiner, Ralf Erdmann and Einat Zalckvar
Double the Fun, Double the Trouble: Paralogs and Homologs Functioning in the Endoplasmic Reticulum
Annual Review of Biochemistry
2019 Publications
Protein Topology Prediction Algorithms Systematically Investigated in the Yeast Saccharomyces cerevisiae.
Bioessays
Coming together to define membrane contact sites.
Nature communications
Luca Scorrano , Maria Antonietta De Matteis , Scott Emr , Francesca Giordano , György Hajnóczky , Benoît Kornmann , Laura L. Lackner , Tim P. Levine , Luca Pellegrini , Karin Reinisch , Rosario Rizzuto , Thomas Simmen , Harald Stenmark , Christian Ungermann & Maya Schuldiner
2018 Publications
Assessment of GFP tag position on protein localization and growth fitness in yeast
J Mol Biol
Genome-wide SWAp-Tag yeast libraries for proteome exploration
Nat Methods
Weill U, Yofe I, Sass E, Stynen B, Davidi D, Natarajan J, Ben-Menachem R, Avihou Z, Goldman O, Harpaz N, Chuartzman S, Kniazev K, Knoblach B, Laborenz J, Boos F, Kowarzyk J, Ben-Dor S, Zalckvar E, Herrmann JM, Rachubinski RA, Pines O, Rapaport D, Michnick SW, Levy ED, Schuldiner M.
Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
Nature communications
Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M and Zalckvar E.
2017
Publications
Targeting and translocation of proteins to the endoplasmic reticulum at a glance
J Cell Sci.
2016
Publications
The SND proteins constitute an alternative targeting route to the endoplasmic reticulum
Nature.
A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites
Dev Cell.
Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor
J Cell Sci.
Making sense of the yeast sphingolipid pathway
J Mol Biol.
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy
Nat Methods.
Water-Transfer Slows Aging in Saccharomyces cerevisiae
PLoS One.
2015
Publications
No peroxisome is an island - Peroxisome contact sites
Biochim Biophys Acta.
Starvation-Dependent Regulation of Golgi Quality Control Links the TOR Signaling and Vacuolar Protein Sorting Pathways.
Cell Rep.
Editorial overview: Cell organelles: Organelle communication: new means and new views
Curr Opin Cell Biol.
Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins.
Mol Cell Biol.
Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies.
Dev Cell.
OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria.
Nat Commun.
Peroxisystem: harnessing systems cell biology to study peroxisomes.
Biol Cell.
2014
Publications
The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.
Mol Cell.
The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis.
FEMS Yeast Res.
A dynamic interface between vacuoles and mitochondria in yeast.
Dev Cell.
Accurate, model-based tuning of synthetic gene expression using introns in S. cerevisiae.
PLoS Genet.
Yeast phospholipid biosynthesis is linked to mRNA localization
J Cell Sci.
A cytosolic degradation pathway, prERAD, monitors pre-inserted secretory pathway proteins.
J Cell Sci.
Peroxisomes are juxtaposed to strategic sites on mitochondria.
Mol Biosyst.
2013
Publications
The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum
PLoS One.
LoQAtE--Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast.
Nucleic Acids Res.
The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein
Mol Cell Biol.
Formation and dissociation of proteasome storage granules are regulated by cytosolic pH
J Cell Biol.
All roads lead to Rome (but some may be harder to travel): SRP-independent translocation into the endoplasmic reticulum.
Crit Rev Biochem Mol Biol.
A novel single-cell screening platform reveals proteome plasticity during yeast stress responses.
J Cell Biol.
From rags to riches - the history of the endoplasmic reticulum.
Biochim Biophys Acta.
2012
Publications
Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis.
Proc Natl Acad Sci U S A.
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes.
Mol Biol Cell.
A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14.
PLoS Biol.
2011
Publications
Getting the whole picture: combining throughput with content in microscopy
J Cell Sci.
Staying in touch: the molecular era of organelle contact sites.
Trends Biochem Sci.
2005-2010
Publications
Explorations in topology-delving underneath the surface of genetic interaction maps.
Mol Biosyst.