Our Laboratory's Research
Functional genomics of organelles
One of the hallmarks of eukaryotic cells is the presence of membrane-enclosed organelles that create optimized environments best suited for promoting the various chemical reactions required to sustain life. Although more than 15 years have passed since the publication of the Saccharomyces cerevisiae genome sequence, over 30% of the proteins that reside in its organelles have never been studied and more than half of them do not have a known biochemical function. Most of these proteins are conserved all the way to humans and some have been implicated in diseases. One of the great challenges of the post-genomic era is, therefore, to use novel methodologies to fill in these gaps in our knowledge, to uncover the functions of these unstudied proteins, and to delineate pathways and networks that enable the function and communication of these organelles. Our lab is dedicated to uncovering novel functions for yeast organellar proteins. We do this by employing a wide variety of high throughput screening techniques complemented by dedicated cell biological, genetic and biochemical follow ups.