If you want to see all publications that our lab has contributed to including collaborative projects please see PubMed:

Here are the central manuscripts that we led:

2021 Publications

The Fast and the Furious: Golgi Contact Sites

SAGE journals 2021 August

Yotam David , Inês G. Castro, and Maya Schuldiner

Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels

JCB journal of cell biology 2021 November

Michal Eisenberg-Bord, Naama Zung, Javier Collado, Layla Drwesh, Emma J. Fenech, Amir Fadel, Nili Dezorella, Yury S. Bykov, Doron Rapaport, Ruben Fernandez-Busnadiego, and Maya Schuldiner

Widespread use of unconventional targeting signals in mitochondrial ribosome proteins

The EMBO journal 2021 November

Yury S. Bykov, Tamara Flohr, Felix Boos, Naama Zung, Johannes M. Herrmann, Maya Schuldiner

2020 Publications

New horizons in mitochondrial contact site research

Biological Chemistry 2020 May

Naama Zung​, Maya Schuldiner

A piggybacking mechanism enables peroxisomal localization
of the glyoxylate cycle enzyme Mdh2 in yeast

Journal of Cell Science 2020

Shiran Gabay-Maskit, Luis Daniel Cruz-Zaragoza, Nadav Shai, Miriam Eisenstein, Chen Bibi,
Nir Cohen, Tobias Hansen, Eden Yifrach, Nofar Harpaz, Ruth Belostotsky, Wolfgang Schliebs,
Maya Schuldiner, Ralf Erdmann and Einat Zalckvar

Uncovering targeting priority to yeast peroxisomes using an in-cell competition assay.

PNAS, 2020 Aug

Rosenthal M, Metzl-Raz E, Bürgi J, Yifrach E, Drwesh L, Fadel A, Peleg Y, Rapaport D, Wilmanns M, Barkai N, Schuldiner M, Zalckvar E.

Double the Fun, Double the Trouble: Paralogs and Homologs Functioning in the Endoplasmic Reticulum

Annual Review of Biochemistry 2020 Jun

Cytosolic Events in the Biogenesis of Mitochondrial Proteins.

Cell Press, 2020 May

Yury S. Bykov, Doron Rapaport, Johannes M. Herrmann and Maya Schuldiner

2019 Publications

Protein Topology Prediction Algorithms Systematically Investigated in the Yeast Saccharomyces cerevisiae.

Bioessays. 2019 Jul

Uri Weill, Nir Cohen, Amir Fadel, Shifra Ben‐Dor, and Maya Schuldiner

High-throughput ultrastructure screening using electron microscopy and fluorescent barcoding.

J Cell Biol. 2019 Jul

Yury S. Bykov, Nir Cohen, Natalia Gabrielli, Hetty Manenschijn, SonjaWelsch, Petr Chlanda, Wanda Kukulski, Kiran R. Patil, Maya Schuldiner, and John A.G. Briggs

Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity

Journal of Cell Science  2019 Jun

Márton Megyeri, Rupali Prasad, Giora Volpert , Andrzej Sliwa-Gonzalez , A. Galih Haribowo, Auxiliadora Aguilera-Romero, Howard Riezman, Yves Barral , Anthony H. Futerman and Maya Schuldiner

The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis.

Contact 2019 Feb

Michal Eisenberg-Bord, Hui S. Tsui, Diana Antunes, Lucía Fernández-del-Río, Michelle C. Bradley, Cory D. Dunn Theresa P. T. Nguyen, Doron Rapaport, Catherine F. Clarke, and Maya Schuldiner

Promethin Is a Conserved Seipin Partner Protein

Cells 2019 Mar

Promethin Is a Conserved Seipin Partner Protein

cells 2019 Jan,

Inês G. Castro, Michal Eisenberg-Bord, Elisa Persiani, Justin J. Rochford,
Maya Schuldiner, and Maria Bohnert 

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2018 Publications

Assessment of GFP tag position on protein localization and growth fitness in yeast

J Mol Biol. 2018 Dec

Defining the Mammalian Peroxisomal Proteome

Subcell Biochem. 2018

Eden Yifrach, Sven Fischer, Silke Oeljeklaus, Maya Schuldiner,
Einat Zalckvar and Bettina Warscheid

An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast

Science. 2018 Sep

Hansen KG, Aviram N, Laborenz J, Bibi C, Meyer M, Spang A, Schuldiner M, Herrmann JM.

Genome-wide SWAp-Tag yeast libraries for proteome exploration

Nat Methods. 2018 Jul

Weill U, Yofe I, Sass E, Stynen B, Davidi D, Natarajan J, Ben-Menachem R, Avihou Z, Goldman O, Harpaz N, Chuartzman S, Kniazev K, Knoblach B, Laborenz J, Boos F, Kowarzyk J, Ben-Dor S, Zalckvar E, Herrmann JM, Rachubinski RA, Pines O, Rapaport D, Michnick SW, Levy ED, Schuldiner M.

Stepping outside the comfort zone of membrane contact site research

Nat Rev Mol Cell Biol. 2018 May

Bohnert M, Schuldiner M.

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

Nat Commun. 2018 May

Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M and Zalckvar E.

Database for High Throughput Screening Hits (dHITS): a simple tool to retrieve gene specific phenotypes from systematic screens done in yeast

Yeast. 2018 Mar

Chuartzman SG, Schuldiner M.

Creating a systematic database of secretory pathway proteins uncovers new cargo for COPI

Traffic. 2018 Mar

Weill U, Arakel EC, Goldmann O, Golan M, Chuartzman S, Munro S, Schwappach B, Schuldiner M.

Validation of a yeast malate dehydrogenase 2 (Mdh2) antibody tested for use in western blots

F1000Res. 2018 Jan

Gabay-Maskit S, Schuldiner M, Zalckvar E.

Mind the Organelle Gap – Peroxisome Contact Sites in Disease

Trends in Biochemical Sciences. 2018 Jan

Castro G. I., Schuldiner M., Zalckvar E.

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2017 Publications

Targeting and translocation of proteins to the endoplasmic reticulum at a glance

J Cell Sci. 2017 Dec

Aviram N, Schuldiner M.

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation

J Cell Biol. 2017 Nov

Eisenberg-Bord M, Mari M, Weill U, Rosenfeld-Gur E, Moldavski O, Castro IG, Soni KG, Harpaz N, Levine TP, Futerman AH, Reggiori F, Bankaitis VA, Schuldiner M, Bohnert M.

Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling

J Cell Sci. 2017 Aug

Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, Schuldiner M.

Two novel effectors of trafficking and maturation of the yeast plasma membrane H+ -ATPase

Traffic. 2017 Jul

Geva Y, Crissman J, Arakel EC, Gómez-Navarro N, Chuartzman SG, Stahmer KR, Schwappach B, Miller EA, Schuldiner M.

A different kind of love - lipid droplet contact sites

Biochim Biophys Acta. 2017 Jun

Schuldiner M, Bohnert M.

Mitochatting - if only we could be a fly on the cell wall

Biochim Biophys Acta. 2017 Apr

Eisenberg-Bord M, Schuldiner M.

Peroxisome Mini-Libraries: Systematic Approaches to Study Peroxisomes Made Easy

Methods Mol Biol. 2017 Apr

Dahan N, Schuldiner M and Zalckvar E.

Pex35 is a regulator of peroxisome abundance

J Cell Sci. 2017 Feb

Yofe I, Soliman K, Chuartzman SG, Morgan B, Weill U, Yifrach E, Dick TP, Cooper SJ, Ejsing CS, Schuldiner M, Zalckvar E, Thoms S.

Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis

J Proteome Res. 2017 Feb

Lebesgue N, Megyeri M, Cristobal A, Scholten A, Chuartzman SG, Voichek Y, Scheltema RA, Mohammed S, Futerman AH, Schuldiner M, Heck AJ, Lemeer S.

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2016 Publications

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

Nature. 2016 Nov

Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M.

A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites

Dev Cell. 2016 Nov

Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor

J Cell Sci. 2016 Sep

Making sense of the yeast sphingolipid pathway

J Mol Biol. 2016 Sep

Ground Control to Major TOM: Mitochondria-Nucleus Communication

FEBS J. 2016 Jun

Eisenberg-Bord M, Schuldiner M.

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

Nat Methods. 2016 Feb

Copy Of -Water-Transfer Slows Aging in Saccharomyces cerevisiae

PLoS One. 2016 Feb

The Protease Ste24 Clears Clogged Translocons

Cell. 2016 Jan

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2015 Publications

No peroxisome is an island - Peroxisome contact sites

Biochim Biophys Acta. 2016 May

Shai N, Schuldiner M, Zalckvar E.

Starvation-Dependent Regulation of Golgi Quality Control Links the TOR Signaling and Vacuolar Protein Sorting Pathways.

Cell Rep. 2015 Sep

Dobzinski N, Chuartzman SG, Kama R, Schuldiner M, Gerst JE.

Editorial overview: Cell organelles: Organelle communication: new means and new views

Curr Opin Cell Biol. 2015 Aug

Schuldiner M, Guo W.

Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins.

Mol Cell Biol. 2015 Sep

Sauerwald J, Jores T, Eisenberg-Bord M, Chuartzman SG, Schuldiner M, Rapaport D.

Lam6 Regulates the Extent of Contacts between Organelles

Cell Rep. 2015 Jul

Elbaz-Alon Y, Eisenberg-Bord M, Shinder V, Stiller SB, Shimoni E, Wiedemann N, Geiger T, Schuldiner M.

Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies.

Dev Cell. 2015 Jun

Moldavski O, Amen T, Levin-Zaidman S, Eisenstein M, Rogachev I, Brandis A, Kaganovich D, Schuldiner M.

OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria.

Nat Commun. 2015 Mar

Lesnik C, Cohen Y, Atir-Lande A, Schuldiner M, Arava Y.

Peroxisystem: harnessing systems cell biology to study peroxisomes.

Biol Cell. 2015 Apr

Schuldiner M, Zalckvar E.

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2014 Publications

The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.

Mol Cell. 2014 Dec

Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK.

The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis.

FEMS Yeast Res. 2014 Nov

Elbaz-Alon Y, Morgan B, Clancy A, Amoako TN, Zalckvar E, Dick TP, Schwappach B, Schuldiner M.

A dynamic interface between vacuoles and mitochondria in yeast.

Dev Cell. 2014 Jul

Elbaz-Alon Y, Rosenfeld-Gur E, Shinder V, Futerman AH, Geiger T, Schuldiner M.

Accurate, model-based tuning of synthetic gene expression using introns in S. cerevisiae.

PLoS Genet. 2014 Jun 26

Yofe I, Zafrir Z, Blau R, Schuldiner M, Tuller T, Shapiro E, Ben-Yehezkel T.

The emergence of proteome-wide technologies: systematic analysis of proteins comes of age

Nat Rev Mol Cell Biol. 2014 Jul

Breker M, Schuldiner M.

Yeast phospholipid biosynthesis is linked to mRNA localization

J Cell Sci. 2014 Aug

Hermesh O, Genz C, Yofe I, Sinzel M, Rapaport D, Schuldiner M, Jansen RP.

A cytosolic degradation pathway, prERAD, monitors pre-inserted secretory pathway proteins.

J Cell Sci. 2014 Jul 15

Ast T, Aviram N, Chuartzman SG, Schuldiner M.

Peroxisomes are juxtaposed to strategic sites on mitochondria.

Mol Biosyst. 2014 Jul

Cohen Y, Klug YA, Dimitrov L, Erez Z, Chuartzman SG, Elinger D, Yofe I, Soliman K, Gärtner J, Thoms S, Schekman R, Elbaz-Alon Y, Zalckvar E, Schuldiner M.

Embracing the void--how much do we really know about targeting and translocation to the endoplasmic reticulum?

Curr Opin Cell Biol. 2014 Aug

Aviram N, Schuldiner M.

The back and forth of cargo exit from the endoplasmic reticulum.

Curr Biol. 2014 Feb

Geva Y, Schuldiner M.

Primers-4-Yeast: a comprehensive web tool for planning primers for Saccharomyces cerevisiae.

Yeast. 2014 Feb

Yofe I, Schuldiner M.

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2013 Publications

The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum

PLoS One. 2013 Dec

Cohen Y, Megyeri M, Chen OC, Condomitti G, Riezman I, Loizides-Mangold U, Abdul-Sada A, Rimon N, Riezman H, Platt FM, Futerman AH, Schuldiner M.

LoQAtE--Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast.

Nucleic Acids Res. 2014 Jan

Breker M, Gymrek M, Moldavski O, Schuldiner M.

The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein

Mol Cell Biol. 2013 Oct

Papić D, Elbaz-Alon Y, Koerdt SN, Leopold K, Worm D, Jung M, Schuldiner M, Rapaport D.

Formation and dissociation of proteasome storage granules are regulated by cytosolic pH

J Cell Biol. 2013 May

Peters LZ, Hazan R, Breker M, Schuldiner M, Ben-Aroya S.

Characterization of an M28 metalloprotease family member residing in the yeast vacuole

FEMS Yeast Res. 2013 Aug

Hecht KA, Wytiaz VA, Ast T, Schuldiner M, Brodsky JL.

All roads lead to Rome (but some may be harder to travel): SRP-independent translocation into the endoplasmic reticulum.

Crit Rev Biochem Mol Biol. 2013 May

Ast T, Schuldiner M.

A novel single-cell screening platform reveals proteome plasticity during yeast stress responses.

J Cell Biol. 2013 Mar

Breker M, Gymrek M, Schuldiner M.

From rags to riches - the history of the endoplasmic reticulum.

Biochim Biophys Acta. 2013 Nov

Schuldiner M, Schwappach B.

A network of cytosolic factors targets SRP-independent proteins to the endoplasmic reticulum.

Cell. 2013 Feb 28

Ast T, Cohen G, Schuldiner M.

The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum.

Cold Spring Harb Perspect Biol. 2013 Mar

Schuldiner M, Weissman JS.

Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked.

J Cell Sci. 2013 Jan

Powis K, Schrul B, Tienson H, Gostimskaya I, Breker M, High S, Schuldiner M, Jakob U, Schwappach B.

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2012 Publications

Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis.

Proc Natl Acad Sci U S A. 2012 Nov

Nadler-Holly M, Breker M, Gruber R, Azia A, Gymrek M, Eisenstein M, Willison KR, Schuldiner M, Horovitz A.

Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes.

Mol Biol Cell. 2012 Oct

Krumpe K, Frumkin I, Herzig Y, Rimon N, Özbalci C, Brügger B, Rapaport D, Schuldiner M.

A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14.

PLoS Biol. 2012 May

Herzig Y, Sharpe HJ, Elbaz Y, Munro S, Schuldiner M.

2011 Publications

Getting the whole picture: combining throughput with content in microscopy

J Cell Sci. 2011 Nov

Rimon N, Schuldiner M.

Protein degradation: BAGging up the trash.

Curr Biol. 2011 Sep

Ast T, Schuldiner M.

Staying in touch: the molecular era of organelle contact sites.

Trends Biochem Sci. 2011 Nov

Elbaz Y, Schuldiner M.

Advanced methods for high-throughput microscopy screening of genetically modified yeast libraries

Methods Mol Biol. 2011

Cohen Y, Schuldiner M.

 2005-2010 Publications

Genetics. The DNA damage road map.

Science. 2010 Dec

Friedman N, Schuldiner M.

Lipids: The plasma membrane code.

Nat Chem Biol. 2010 Jul;

Futerman AH, Schuldiner M.

Explorations in topology-delving underneath the surface of genetic interaction maps.

Mol Biosyst. 2009 Dec

Breker M, Schuldiner M.

Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.

Science. 2009 Mar

Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M.

The GET complex mediates insertion of tail-anchored proteins into the ER membrane.

Cell. 2008 Aug

Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS.

Identification of yeast proteins necessary for cell-surface function of a potassium channel.

Proc Natl Acad Sci U S A. 2007 Nov

Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M.

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Cell. 2005 Nov

Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ.